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Fully validated highly sensitive method enables completion of thyroid hormone tests in accordance with OECD guidelines
February 21, 2017
By: Tim Wright
Editor-in-Chief, Contract Pharma
Envigo has developed and validated a robust analytical method to evaluate the potential effects on thyroid hormone levels in rat F1 offspring. It is now possible for the company to successfully determine levels of T3 (triiodothyronine) and T4 (thyroxine) hormones in serum from rats at days 4 and 13 of age using ultra high pressure liquid chromatography coupled to a high-end tandem mass spectrometer (UHPLC-MS/MS) for detection. As a result, OECD reproductive toxicology guidelines OECD 421, 422 an...
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